What is the Sedation Troetsch?

  • You will be given a sublingual (under-the-tongue) tablet known as a Troetsch before your procedure. This Troetsch is designed to help reduce anxiety and discomfort and contains the following medications:
  • Medazepam 3 mg – a benzodiazepine used to relieve anxiety and induce mild sedation.
  • Ketamine 25 mg – a dissociative anesthetic used in low doses for pain control and relaxation.
  • Ondansetron (Zofran) 4 mg – an anti-nausea medication to reduce the risk of vomiting or nausea.

This medication is absorbed under the tongue and begins working within 15–30 minutes.

Anesthesia Pill

Potential Benefits

  • Reduced anxiety and stress before the procedure
  • Enhanced comfort during minor procedures
  • Lower need for intravenous sedation
  • Decreased risk of nausea with the addition of ondansetron

Possible Side Effects

Common side effects may include:

  • Drowsiness or lightheadedness
  • Altered perception or mild euphoria
  • Dry mouth or slight numbness under the tongue

Less common but possible effects:

  • Nausea or vomiting
  • Confusion or disorientation
  • Allergic reaction (rash, swelling, breathing difficulty)
  • Hallucinations or unusual thoughts (rare at low doses of ketamine)
  • Please inform your healthcare provider if you have a history of sensitivity to any of the above medications.

Warnings and Precautions

  • Do not drive, operate machinery, or make major decisions for at least 12 hours after taking this medication.
  • You must have a responsible adult accompany you home after the procedure.
  • Tell your doctor if you are pregnant, breastfeeding, or have liver disease, glaucoma, psychiatric conditions, or a history of substance abuse.
  • Inform your provider about all medications you are currently taking, including antidepressants, opioids, and sedatives.